Primary Research by winningthefight.org
DEANNA PROTOCOL METABOLIC THERAPY IN TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
- What this article proves: the potential link between ALS and Borrelia infection, highlighting impaired cell energy production as a common factor. It introduces the Deanna Protocol, a metabolic therapy aimed at alleviating ALS symptoms, with promising preliminary results. Additionally, environmental factors like exposure to fossil fuels and insecticides are explored as potential contributors to ALS incidence. While offering intriguing insights, further research is needed to validate these findings and develop effective treatments for ALS patients.
- Link to Article: Click Here
- If link above is broken, look for article online using the title of article.
EVALUATION OF HOLISTIC TREATMENT FOR ALS REVEALS POSSIBLE MECHANISM AND THERAPEUTIC POTENTIAL
- What this article proves: the Deanna protocol corrects the mal-alignment of the microtubules that connect nerve cells to nerve cells and nerve cells to muscle. The microtubules are the pathways down which signaling occurs between cells. The function of the Tau protein is to maintain this alignment hence the Deanna Protocol restores the function of the Tau protein. Dementia is caused by abnormal signaling between brain nerve cells. Muscle symptoms are caused by abnormal signaling between nerves and muscles. Every neurodegenerative disease has dysfunctional Tau protein hence the Deanna protocol is beneficial in all neurodegenerative diseases such as ALS, AD, MS, PD and others. See link to article listed below.
- Link to Article: Click Here
- Link to Article About the Study: Click Here
- If link above is broken, look for article online using the title of article.
HUMAN CELL STUDIES FIND DEANNA PROTOCOL EFFECTIVE
- What this article proves: The Deanna Protocol is effective in correcting neuromuscular junction deficits in human ALS cells
- Link to Study: https://onlinelibrary.wiley.com/doi/10.1002/adtp.202000133
- Link to Article About the Study: Click Here
- If link above is broken, look for article online using the title and the source.
- The original title of the study is: A Human Based Functional NMJ System for Personalized ALS Modeling and Drug Testing
- The original title of the article is referencing the study is: ALS Chip Model Closely Mimics Disease May Aid Research
- Study Source: University of Central Florida
*Note: This study was not funded by Winning the Fight, but since the study directly tested the Deanna Protocol, it has been included under primary research page instead of the secondary research page (because the secondary research page mainly houses supporting evidence rather than direct studies on the Deanna Protocol).
STUDIES COMBINING DP PLAN WITH OTHER SUBSTANCES
- Glutamic-Oxaloacetic Transaminase Combined with Metabolic Therapy in a Mouse Model of Amyotrophic Lateral Sclerosis; Published to Site: April 30, 2017
DEANNA PROTOCOL ON CULTURED HUMAN MOTONEURONS IN VITRO
PLOS ONE JOURNAL STUDY
- Metabolic Therapy with Deanna Protocol Supplementation Delays Disease Progression and Extends Survival in Amyotrophic Lateral Sclerosis (ALS) Mouse Model – PLOS ONE Journal (ID #:PONE-D-14-14612R1); Accepted June 30, 2014 (in press)
Abstract
- Increased TCA cycle intermediates in response to diet with Deanna protocol in ALS mouse model (578.3) – The FASEB Journal vol. 28 no. 1 Supplement 578.3; April 2014
- Effect of Alternative Metabolic Fuels as a Potential ALS Therapy in Mice and Humans (poster for Atlanta Conference 2013) Published to Site: July 31, 2013
DR. TEDONE’S 2013 VIDEO PRESENTATION OF RESEARCH PRIOR TO COMPLETION OF MOUSE STUDIES ABOVE
Dr. Tedone will record an updated video in 2017. (Please note – The Dr. Tedone calls the Deanna Protocol Plan the “Deanna Protocol” or the “DP” for the sake of simplicity, but the legal and official name is the the Deanna Protocol Plan.)
Primary Annecdotal Research by Winning the Fight
Below is an excerpt from a list of testimonies from 26 individuals with ALS, who testified that the Deanna Plan reversed, stopped, or slowed the progression of their ALS. Their ALSFRS scores reflect the accuracy of their testimonies.
Deanna Tedone-Gage
My father experimented with a number of supplements until we realized that taking three particular supplements (coconut oil, A-AKG and GABA) were reversing my disease. My coordination, speech, walking, and breathing improved. My twitching and tremors also lessened dramatically. Friends and family members noted my improvement and began to spread the word to others who had loved ones with ALS.
MJBUK
My answer is YES, I believe the Deanna Protocol has helped me and I am better than I would have been if I had not been on it.
DBLTREE
I started March 18th, 2013 and the Deanna Protocol has helped my swallowing, excess saliva, speech, balance and walking and I have maintained an ALSFRS of 43. I am thankful for the quality of life extension granted by God and the Deanna Protocol.
Andrew
Diagnosed with ALS in December 2011. Before doing the Deanna Protocol, I was in a steep decline for several months. I started the Deanna Protocol in December 2012. Immediately there was an improvement in breathing and muscle strength. For the approximately 6 months since, I have maintained my ALSFRS score. Thank you Deanna and Dr. Tedone. I have no doubt that I’d be stuck in bed by now without your Protocol.
Andrew
I started the Deanna Protocol and here are the results by month:
Walking with walker
Mo. 0 about 20 ft
Mo. 1 about 50 ft
Mo. 2 about 100 ft
Mo. 3 about 100 ft
Mo. 4 about 50 ft
Mo. 5 about 40 ft
Arm strength and hand grip measured in pulley fly repetitions
Mo. 1 28
Mo. 2 100
Mo. 3 200
Mo. 4 250
Mo. 5 300
Breathing measured by spirometer has been good and steady.
I had a temporary dip in months 4 and 5 in walking because I changed the A-AKG supplier which was a mistake. I have since gone back to NOW which seems to work best for me.
I think that getting the right amount of exercise is the key. Concentrate on enough cardio and stretching and very light strength and resistance. I think more frequency is better than long exhausting reps. A little bit at a time more often.
I was in a steep decline prior to starting the Deanna Protocol. So steady is outstanding for 5 months. Also, I am taking 180 g of protein a day.
Click Here: Read Full Report
Winning the Fight’s Research in Progress
GOT & Deanna Protocol Plan Combination Study
- Winning the Fight is currently conducting a mouse study, at the University of South Florida, that is testing the impact of the combination of the Deanna Protocol Plan and GOT (a substance that will convert glutamate to glutamine to enable the body to expel excess glutamate). GOT was discovered at the Weizmann Institute of Science in Israel.
Secondary Research by winningthefight.org
Research on Arginine (Substance in AAKG Supplement in Deanna Protocol Plan)
Arginine Corrected Metabolic Dysfunction in Children with Mitochondrial Diseases
- What this article proves: One of the substances in the Deanna Protocol Plan is arginine. Its purpose, along with Alpha ketoglutarate, is to deliver energy to the Kreb’s Cycle and, thereby, help the mitochondria function and prevent cells from dying. This piece of literature shows evidence that arginine is effective in correcting malfunctioning mitochondria.
- Link: https://www.newswise.com/articles/intravenous-arginine-benefits-children-after-acute-metabolic-stroke?sc=mwhn
- If link above is broken, look for article online using the title and the source.
- The original title of the article is: Intravenous Arginine Benefits Children after Acute Metabolic Stroke
- Source: Children’s Hospital of Philadelphia
Research on Bacteria and Neurodegenerative Diseases
ALS Patients Test Positive for Borrelia Infection
- What this article proves: This article proves that ALS is likely caused by the bacteria that belongs to the genus borrelia. Up until now, borreila was only thought to be the cause of Lyme disease, but Dr. Tedone hypothesizes that it also causes ALS. The borrelia bacteria is very hard to detect in the body because, unlike other bacteria, the spirochete bacteria (spiral shaped bacteria) burrows into the soft tissue and is not present in the blood (other than red blood cells). Most tests for borrelia are inefficient at detecting bacteria in soft tissue.
- Link: https://www.americanintegrative.com/wp-content/uploads/2016/06/ALS-and-LYme-I-am-pleased-to-announce-the-following.pdf
- If link above is broken, look for email online using the title and the source.
- The original title of the email is: I am pleased to announce the following
- Source: American Integrative Pharmacy; Martin Atkinson-Barr PhD
News Article – Woman Diagnosed with MS Actually Had Borrelia Infection (Lyme Disease)
- What this article proves: The link between MS and borrelia
- Link to original article: https://www.dailymail.co.uk/health/article-2343062/Mother-diagnosed-MS-facing-life-wheelchair-cured–discovered-symptoms-TICK-BITE.html
- If link above is broken, look for article/study online using the title and the source.
- The original title of article is: Mother diagnosed with MS and facing life in a wheelchair is cured – after she discovered her symptoms were due to a TICK BITE
- Source: DailyMail UK
News Article – Massachusetts Woman Diagnosed with ALS Dies of Borrelia Infection (Lyme Disease)
- What this article proves: The link between ALS and borrelia
- Link to original article> https://www.huffpost.com/entry/man-diagnosed-with-als-di_b_8891262
- If link above is broken, look for article/study online using the title and the source.
- The original title of is: Mother diagnosed with MS and facing life in a wheelchair is cured – after she discovered her symptoms were due to a TICK BITE
- Source: DailyMail UK
Borrelia Infection in Multiple Sclerosis
- Source: Alan McDonald, MD, FCAP – Dr. Paul H. Duray Research Fellowship Endowment, Inc
- What these videos prove: Multiple Sclerosis is likely caused by a borrelia infection.
- Link to Video 1: https://vimeo.com/166688480
- If link above is broken, look for video online using the title and the source. The original title of the video is: Alan McDonald London Lecture May 2016
- Link to Video 2: https://vimeo.com/user27613099
- If link above is broken, look for video online using the title and the source.
- The original title of the video is: London Lecture May 15 2016
Source: Dr. Alan MacDonald
Bacteria Found in Alzheimer’s Brain Post-Mortem
- What this article proves: Alzheimer’s Disease, like ALS, is likely linked to bacterial infection with borrelia
- Link to original video: https://vimeo.com/158001419
- If link above is broken, look for article/study online using the title and the source.
- The original title of article is: Final Lecture German Borreliosis Society Alan B MacDonald Lecture March 11 2016
- Source: Alan MacDonald
Borrelia Detected in the Brains of Alzheimer’s Patients
- What this article proves: The connection between borrelia bacteria and Alzheimer’s Disease
- Link to original article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171359/
- If link above is broken, look for article/study online using the title and the source.
- The original title of article is: Alzheimer’s disease – a neurospirochetosis. Analysis of the evidence following Koch’s and Hill’s criteria
- Source: Journal of Neuroinflammation
- Author: Judith Miklossy
Borrelia Present in Alzheimer’s Disease
- What this article proves: The connection between borrelia bacteria and Alzheimer’s Disease
- Link to original article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171359/
- If link above is broken, look for article/study online using the title and the source.
- The original title of article is: Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease.
- Source: Journal of Alzheimer’s Disease
- Author: Miklossy J1, Khalili K, Gern L, Ericson RL, Darekar P, Bolle L, Hurlimann J, Paster BJ.
Disulfiram Cures Borrelia Infection
- What this article proves: Disulfiram Cures Borrelia Infection
- Link to original article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627205/
- If link above is broken, look for article/study online using the title and the source.
- The original title of article is: Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis: Report of Experience in Three Cases
- Source: Antibiotics (Journal)
- Author: Kenneth B. Liegner
- Authors: Summer B. Gibson, Jonathan M. Downie, Spyridoula Tsetsou, Julie E. Feusier, Karla P. Figueroa, Mark B. Bromberg, Lynn B. Jorde, Stefan M. Pulst
Research on the Blood Brain Barrier
Blood Brain Barrier is impaired in ALS patients
- What this article proves: This study shows that the BBB in someone with ALS does not function normally and certain substances that normally should not be able to pass through the BBB are able to pass through in those with ALS. This is significant because some substances in the Deanna Protocol cannot pass the BBB in healthy patients. However, in those with ALS, who have a malfunctioning BBB, the substances are able to pass through. This allows these substances to make a positive impact on patients with ALS. For the layperson: the blood brain barrier is a highly selective semipermeable border that separates the blood from the brain (BBB). The BBB “chooses” what substances are allowed to cross through to the brain and which are not. Many medications and substances introduced into the blood cannot pass the BBB, which means they cannot impact the brain and nervous system.
- Link to original article: https://www.frontiersin.org/articles/10.3389/fncel.2014.00021/full
- If link above is broken, look for article/study online using the title and the source.
- The original title of is: Blood–CNS barrier impairment in ALS patients versus an animal model
- Source: Frontiers in Cellular Neuroscience
- Authors: Svitlana Garbuzova-Davis1,2,3* and Paul R. Sanberg
Blood Brain Barrier Breaks Down During Inflammation
- What this article proves: The Blood Brain Barrier is not in tact when inflammation occurs
- Link to original article: https://stm.sciencemag.org/content/9/397/eaai9111.full
- If link above is broken, look for article/study online using the title and the source.
- The original title of is: Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica
- Source: Science Translational Medicine: Neurobiology
- Author: Fumitaka Shimizu1,*, Kristin L. Schaller2,*, Gregory P. Owens2, Anne C. Cotleur3, Debra Kellner3, Yukio Takeshita1, Birgit Obermeier3, Thomas J. Kryzer4, Yasuteru Sano1, Takashi Kanda1, Vanda A. Lennon4, Richard M. Ransohoff3,† and Jeffrey L. Bennett2,†
Research on Toxins and Neurodegenerative Disease
The articles below support Dr. Tedone’s point that toxins likely play a role in ALS and neurodegenerative disease. In 2009, when Dr. Tedone began his research, mainstream medicine did not accept that toxins play a role in ALS and the popular opinion was that non-genetic forms of ALS happened completely at random. Now, the role of toxins in ALS is documented and becoming more accepted in mainstream medicine. New research has given light to a new theory. According to Dr. Tedone and some others studying neurodegenerative diseases, borrelia bacteria is likely the real cause of neurodegenerative disease. Toxins are likely just an aggravator. What does this mean? Someone can have this bacteria in the body for a long time (even decades) without being sick because the immune system can keep the bacteria under control and prevent it from multiplying enough to cause disease. Dr. Tedone and his colleagues hypothesize that environmental factors (such as toxins and stress) can suppress the immune system and prevent it from keeping the bacteria under control. A suppressed immune system allows the bacteria that’s already there to multiply, attack the nervous system, and cause disease. While the studies below don’t address borrelia bacteria and its role in ALS, they do address the fact that toxins in the environment are strongly correlated with onset of neurodegenerative disease symptoms.
ALS from Mercury in Amalgam Fillings
- What this article proves: A toxin, Mercury, could possibly be a cause of ALS, likely if the borrelia bacteria is already present in the body.
- Link to original article here: https://www.ncbi.nlm.nih.gov/pubmed/28641283
- If link above is broken, look for article/study online using the title and the source.
- The original title of is: Healing of Amyotrophic Lateral Sclerosis: A Case Report
- Source: Science Translational Medicine: Neurobiology
- Author: Healing of Amyotrophic Lateral Sclerosis: A Case Report
Three Teachers in Same Classroom Suffer from ALS
- What this article proves: ALS is only present in roughly .00595% of the American population (about 16,000 people out of the 270 million living in the U.S.). Due to the rarity of this disease odds of three unrelated teachers who worked in the same classroom all randomly contracting ALS by chance are extremely low. This leads to the probability that their ALS as brought on by an environmental cause. The full article is only available by paid subscription to medical research journals, but the abstract is here.
- Link to original article here: https://www.ncbi.nlm.nih.gov/pubmed/3655851
- If link above is broken, look for article/study online using the title and the source.
- The original title of is: Three cases of amyotrophic lateral sclerosis in a common occupational environment
- Source: Department of Neurology, Ohio State University Medical Center
- Author: Hyser CL1, Kissel JT, Mendell JR.
Toxins in Blue Green Algae Can Cause Nerve Degeneration
- What this article proves: This study proves that environmental factors such as toxins (and a particular toxin called BAMA in blue green algae) can cause neurodegenerative disease.
- Link to article: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075376
- If link above is broken, look for article/study online using the title and the source.
- The original title of is: The Non-Protein Amino Acid BMAA Is Misincorporated into Human Proteins in Place of L-Serine Causing Protein Misfolding and Aggregation
- Source: PLOS One Research Journal
- Author: Rachael Anne Dunlop1, Paul Alan Cox2, Sandra Anne Banack2, Kenneth John Rodgers1*
Lead Exposure as a Risk Factor for ALS
- Source: National Institute for Environmental Health Sciences
- What this article proves: This article proves that lead exposure is linked to increase probability of ALS.
- Link to article: https://www.ncbi.nlm.nih.gov/pubmed/16909025
- If link above is broken, look for article/study online using the title and the source.
- The original title of is: Lead Exposure as a Risk Factor for Amyotrophic Lateral Sclerosis
- Author: Kamel, F; Umbach, DM; Hu, H; Munsat, TL; Taylor, JA; Sandler, JP
List of Toxins and How They Impact the Body
- What this document proves: This document is a list of poisons known to cause neurological disease
- Link to article: There is no link. This is a snippet from a medical book.
- Book: Casarett & Doull’s Toxicology. The Basic Science of Poisons, 8th (2013).
Workplace Exposure to Toxins & ALS
- Source: National Institute of Environmental Health Sciences
- What this document proves: This document proves that construction workers and precision metal workers, who are exposed to a variety of toxins in their daily work, are more likely to have ALS.
- Link to article: https://www.ncbi.nlm.nih.gov/pubmed/27418175
- If link above is broken, look for article/study online using the title and the source.
- The original title of is: Occupational exposures and the risk of amyotrophic lateral sclerosis.
- Source: Peters TL1,2, Kamel F2, Lundholm C1, Feychting M3, Weibull CE1, Sandler DP2, Wiebert P4, Sparén P1, Ye W1, Fang F
Research on ALS & Genetics
The Evolving Genetic Risk for Sporadic ALS
- What this article proves: There is a genetic component to sporadic ALS. Dr. Tedone believes it’s possible that the borrelia bacteria in ALS (when they reproduce) enter the cells and interrupt the energy cycle of the cell. In doing so, they cause gene mutations in the cell.
- Link to original article: https://n.neurology.org/content/89/3/226
- If link above is broken, look for article/study online using the title and the source.
- The original title of article is: The evolving genetic risk for sporadic ALS
Source: American Academy of Neurology